Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitis.

Moreover, the expression of receptors of above mentioned pro-inflammatory factors showed an increasing trend in cholangiocytes or stellate cells, such as Tnfrsf1a (Stellate cell: log 2 FC = 0.14, adjust- P = 0.006), Tnfrsf1b (Stellate cell: log 2 FC = 0.12, adjust- P = 0.02; Cholangiocyte: log 2 FC = 0.29, P = 0.005, adjust- P = 1), Il1r1 (Stellate cell: log 2 FC = 0.34, P = 0.002, adjust- P = 1).

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