Reduced WNT4 expression in normal skin fibroblasts leads to 'Dupuytren-like' changes in the transcriptome.

Fibroblasts from normal skin of DD positive participants have a significantly different transcriptome compared to fibroblasts from normal skin tissue from DD negative tissue In light of the genetic predisposition to DD in the family being studied, we hypothesised that there may be significant changes even in the phenotypically normal fibroblasts isolated from the wrists of these participants that is indicative of a predisposition to develop DD compared to those from healthy non-DD participants.

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