Construction and validation of an immune-related gene signature predictive of survival and response to immunotherapy for colorectal cancer.

As shown in Figure 10 , the expression of immune checkpoints in the low-risk group showed an increasing trend, among which PD-L1 expression was significantly elevated in both cohorts (TCGA: P < .01; GSE39582 : P < .05), CTLA4 and TIGIT were significantly higher in TCGA cohort ( P < .05), and LAG3 was significantly higher in GSE39582 cohort ( P < .05).

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In general, immune cells showing positive effects on OS tended to aggregate in the TIME of the low-risk group, while the proportion of immune cells with negative effects on OS showed a decreasing trend in the low-risk group.

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