Dose-dependent responses to canonical Wnt transcriptional complexes in the regulation of mammalian nephron progenitors.

Examining DEGs shared between both β-catenin removal conditions in high CHIR cultured NPCs identified a highly significant response (hypergeometric test: P -value for upregulated, 3.07E-1664; P -value downregulated, 3.675e-776) with 937 shared DEGs: 655 upregulated and 282 downregulated after β-catenin KO, many of which exhibited β-catenin/Tcf7/Lef1 ChIP seq binding associated with the gene locus ( Fig. 5A,B ; Tables S1.17-S1.20 ; Table S2 ).

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