iWD alters resident-like macrophages Notably, we found that most of the highly significant macrophage DEGs (Fig. 2b and Supplementary Table 1 ) were enriched in resident-like macrophages, for example, aortic-intima-resident-like (Mac AIR ) macrophages, adventitial and intimal TLF-like (expressing TIMD4 and/or LYVE1 and/or FOLR2) macrophages, and were downregulated under a iWD versus a cWD (Fig. 2b and Supplementary Table 3 ).
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Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis.
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