The sphingosine kinase 2 inhibitors ABC294640 and K145 elevate (dihydro)sphingosine 1-phosphate levels in various cells.

Contrary to expectations, incubations of Chang, HepG2, and HUVEC cells with ABC294640 or K145 resulted in highly significant increases in cellular S1P ( Fig. 2 ).

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Remarkably, even in the presence of FB 1 , the detectable amount of dhSph was still elevated compared to the solvent control, significant for K145 and borderline significant for ABC294640.

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