Considering the full set of pairs of genes that can be obtained from Human1, where 14,128 out of 6,579,378 are paralogue pairs of genes (according to the Ensemble annotation), this is a highly significant result (Hypergeometric test p -value: 7.28 × 10 −11 ), in line with previous studies suggesting that the fraction of synthetic lethal pairs is significantly higher between paralogue gene pairs compared to the pairs of randomly selected genes 14 .
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An automated network-based tool to search for metabolic vulnerabilities in cancer.
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