Complete absence of GLUT1 does not impair human terminal erythroid differentiation.

However, gene ontology enrichment analysis revealed a highly significant enrichment of glycolysis-associated proteins ( P < 10 10 ), with downregulation of the entire glycolytic pathway, and conversely an upregulation of AMP-activated protein kinase signaling– and autophagy-associated proteins, promoting catabolic pathways to generate more ATP.

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Most importantly, elevation in all lysophospholipids (significant for lysophosphatidylethanolamine, borderline significant for lysophosphatidylserines and lysophosphatidylcholine, as seen in Figure 5 C-E) are suggestive of increased phospholipase activity upon activation of the Lands cycle for the repair of damaged lipids in the KO group.

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