Current Updates of CRISPR/Cas System and Anti-CRISPR Proteins: Innovative Applications to Improve the Genome Editing Strategies.

The fusion of Acr variants with Cas9 also decreases off-targeting effects, which is practically significant. 142 Although it has been demonstrated that base editing via the fusion of dCas9 with a cytidine deaminase can effectively correct point mutations related to genetic diseases without causing significant harmful double-strand breaks in DNA. 143 This can also result in single-nucleotide variants in m

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