Diagnostic Performance of Host and Viral DNA Methylation Analysis in the Identification of Anal Intraepithelial Neoplasia and Cancer: Systematic Review and Meta-Analysis.

Results of Meta-Analysis The pooled prevalence of methylation-positive results by different histological gradings showed an increasing trend between specimens with low- and high-grade anal lesions, with a pooled prevalence of 0.27 (95% CI: 0.09–0.51), 0.45 (95% CI: 0.33–0.58), 0.54 (95% CI: 0.39–0.68), and 0.98 (95% CI: 0.94–1.0) in AIN1 and LSIL, AIN2 and HSIL, AIN3, and SCC, respectively ( Table 3 , Figure 2 , Figure 3 , Figure 4 and Figure 5 ).

also in 63,971 other papers