Effect of CFTR Modulators on Oxidative Stress and Autophagy in Non-CFTR-Expressing Cells.

Teza and Iva caused a significant increase in the total levels of polyubiquitinated (PolyUb) proteins, while an increasing trend was seen with Elexa ( Figure 1 E,F). p62/SQSTM1 (referred to below as p62) which acts as an autophagy receptor [ 35 ], recognizing and binding to ubiquitinated proteins and organelles that need to be degraded, was increased with Elexa, Iva and ET ( Figure 1 D,F).

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