Plasma levels of both total adiponectin and high molecular weight adiponectin (HMW) were also inversely related to the BMI, insulin resistance, and triglyceride levels, showing a decreasing trend in obesity that is reversible with weight loss [ 76 , 77 ].
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The Role of Adipokines between Genders in the Pathogenesis of Osteoarthritis.
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However, the prevalence of knee OA has also significantly increased among younger age groups (0–34 years, 35–39 years, and 40–44 years), reflecting an unexpected trend towards younger onset [ 9 ].