highly significantP < 0.01
*: indicates significant difference ( P < 0.05), **: indicates that the difference is highly significant ( P < 0.01) and ns: indicates no significant difference ( P > 0.05).
*: indicates significant difference ( P < 0.05), **: indicates that the difference is highly significant ( P < 0.01) and ns: indicates no significant difference ( P > 0.05).