Tissue niche influences immune and metabolic profiles to Staphylococcus aureus biofilm infection.

Interestingly, similar increases in intracellular purine and pyrimidine metabolites were observed in granulocytes across models at day 14 but failed to reach significance at days 3 or 7 post-infection (Fig. 6C ), and intracellular purines differed over time, specifically in granulocytes from the galea but not PJI tissue (Fig. 6D ).

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