Mesothelin expression correlates with elevated inhibitory immune activity in patients with colorectal cancer.

Cancer Gene Ther · 2024 · PMC11489080 · PMID 39174744

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highly significantno p-value reported

Additionally, immune-related pathways including IFN-γ Response (NES = 1.44, FDR = 0.02), IL2 STAT 5 Signaling (NES = 1.37, FDR = 0.06), IFNα Response (NES = 1.37, FDR = 0.07), IL6 JAK STAT3 Signaling (NES = 1.36, FDR = 0.07), and TNFα Signaling via NFKβ (NES = 1.39, FDR = 0.09) were all highly significant in the MSS cohort.

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