borderline significantp = 0.058
The genetic profile of the LNMs from PTC patients harboring 4 or more DMs revealed a significantly higher frequency of TERT promoter mutations than the LNMs from PTC patients harboring less than 4 DMs (96% vs 65%, p < 0.001), and a higher frequency of ATM pathogenic mutations, being such difference borderline significant (11% vs 0%, p = 0.058) (Supplementary Fig.