857 Furthermore, the activation of RLRs, such as RIG-I and MDA5, plays a crucial role in antiviral defense mechanisms and may be significant in cancer treatment by promoting immunogenic cell death in tumor cells. 858 Polymer nanoparticles delivering synthetic RIG-I agonists have shown potential anti-tumor effects, including promoting cell death and modulating the tumor microenvironment. 859 Designed pH-responsive polymer nanoparticles h
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