Optimization of a lentivirus-mediated gene therapy targeting HIV-1 RNA to eliminate HIV-1-infected cells.

At an MOI of 14, the highest concentration tested, transduction with D4 or D4 opt 1 resulted in a highly significant reduction in viability when Jurkat cells were additionally treated with GCV: 113% to 34.0% for D4 and 114% to 39.8% for D4 opt 1 ( Figure 2 G).

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