Effect of Ritanserin and Duloxetine on the Gene Expression of Primary Aniridia and Healthy Human Limbal Stromal Cells, In Vitro.

In our present study, even though we did not see significant changes in the levels of PAX6 and TGF-β1 mRNA expression in any of the duloxetine-treated groups, there was still a slight trend in PAX6 upregulation and TGF-β1 downregulation after duloxetine treatment in all groups.

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However, there were highly variant CT values of ACTA2A1 mRNA expression 24 h after ritanserin treatment, which might indicate a possibly significant decrease using a prolonged ritanserin treatment.

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