Gut microbiota-derived gamma-aminobutyric acid improves host appetite by inhibiting satiety hormone secretion.

In terms of orexigenic hormones, although the relative mRNA expression of Ghrelin in the High group was similar to that in the Low group, there was an increasing trend in its serum levels ( Fig. 2A and F ).

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The results indicate a significant or highly significant positive correlation between GABA levels and the relative abundance of NPY levels and ADFI, while showing a significant or highly significant negative correlation with PYY, CLP-1, CCK, and POMC levels ( Fig. 5I ).

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