Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.

The S-UMAP analysis revealed highly significant correlations between EpCAM in lymphoid restricted regions, where elevated IFNγ and NOS2 were expressed, either at the tumor edge or in tumor satellites areas ( Fig. 6B ).

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