Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis and Regulates a Schizophrenia Susceptibility Gene Network within the Mouse Dentate Gyrus.

We found that the protein products of genes within the WGCNA modules had highly significant functional interactions forming densely interconnected networks ( Fig. 14 A , mouseUP module, 1,136 nodes; average node degree, 8.2; PI enrichment p value = 3.56 × 10 −13 ; Figure 14 C , mouseDOWN module, 712 nodes, average node degree, 15; PI enrichment p value < 1.0 × 10 −16 ).

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