In this respect, it may be significant that NSN-to-SN transition, i.e., karyosphere formation, is accompanied by a change in the specific pattern of epigenetic markers (modified histones) in mouse [ 17 ], porcine [ 18 ], and human oocytes [ 19 ].
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How the Oocyte Nucleolus Is Turned into a Karyosphere: The Role of Heterochromatin and Structural Proteins.
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