A cocktail of Cu<sup>2+</sup>- and Zn<sup>2+</sup>-peptoid-based chelators can stop ROS formation for Alzheimer's disease therapy.

4 a Along with sufficient affinity for Cu over other metal ions, high selectivity for Cu over Zn is extremely significant because Zn is co-present in the synaptic cleft at a higher concentration than Cu, thus it is more available for coordination by Aβ. 8 Moreover, as the affinity of Aβ to Zn 2+ is lower than its affinity to Cu, 7 a ,9 it is possible that the Cu-chelator will bind Zn 2+ ions rather than extracting Cu 2+ ions from the toxic Cu–Aβ complex (due to the similarities in the binding preferences of these two metals), 4 a ,10 thus hindering the inhibition of ROS production.

also in 7,787 other papers