Synthesis and Biological Activity Assessment of 2-Styrylbenzothiazoles as Potential Multifunctional Therapeutic Agents.

Products of other LO isoforms were not significantly affected by the test compounds ( Figure 2 F), with the notable exception of BZTst1 (weak but significant inhibition of 12-HETE) and BZTst4 (highly significant inhibition of 12-HETE). 3.5.2. 5-Lipoxygenase Inhibition in Cell-Free and Cell-Based Assays The inhibitory activity of the compounds against 5-LO was further explored using another cell-based assay involving A23187-stimulated human PMNL, and a cell-free assay employing isolated human recombinant 5-LO enzyme.

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