Trends in Antimicrobial Consumption in Tertiary Care Hospitals in Costa Rica from 2017 to 2021: A Comparative Analysis of Defined Daily Doses per 100 Bed Days and per 100 Discharges.

Moreover, an increasing trend in the consumption of azole antifungals was reported.

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mption per year), X: the year or time (independent variable), and ε: the error term (captures the variability not explained by the linear relationship) If β1 (the slope) is positive, it suggests an increasing trend in antimicrobial consumption over the 5-year period; if β1 is negative, it indicates a decreasing trend; and if β1 is close to zero and not statistically significant, it suggests no significant trend in consumption over time.

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