After administering arsenic to C57BL/6 male mice, a decreasing trend in AQP7 was found in both visceral white adipose tissue (epididymal and retroperitoneal) and subcutaneous white adipose tissue, with the perirenal white adipose tissue the most affected [ 85 ].
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The sentences
Some obese patients exhibited a decreasing trend in the concentrations of AQP7 mRNA or protein in visceral white adipose tissue [ 90 ], while others showed an increasing trend in AQP7 mRNA levels [ 92 , 93 ].