Lack of Association Between BsmI and FokI Polymorphisms of the VDR Gene and Sporadic Colorectal Cancer in a Romanian Cohort-A Preliminary Study.

However, while our findings suggest that these particular polymorphisms may not be significant risk factors for CRC in this cohort, future research should explore the broader implications of VDR polymorphisms, particularly in relation to cancer progression, recurrence, survival, and drug resistance.

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In a case-control study conducted by Cho et al., no significant association with CRC risk was found, but a borderline significant association for a lower risk of colon cancer in heterozygous carriers was observed.

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