Hypoxia Modulates Sodium Chloride Co-transporter via CaMKII-β Pathway: An In Vitro Study with mDCT15 Cells.

Of note, the membrane-bound NCC was significantly increased after 1 h of CoCl 2 treatment ( p = 0.020) and after 24 h of CoCl 2 treatment ( p = 0.004) in line with the above-mentioned HIF1alpha expression, indicating that long-term CoCl 2 treatment had a highly significant promoting effect on NCC activation ( Figure 2 a,e).

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