TGFB2 mRNA Levels Prognostically Interact with Interferon-Alpha Receptor Activation of IRF9 and IFI27, and an Immune Checkpoint LGALS9 to Impact Overall Survival in Pancreatic Ductal Adenocarcinoma.

Int J Mol Sci · 2024 · PMC11508538 · PMID 39457004

Europe PMC DOI

hedged sentences

0.0040

closest p · 0.1× alpha

0.0600

boldest claim

The sentences

highly significantp = 0.004actually significant

The M2 marker, MRC1/CD206, showed a highly significant impact for TGFB2 in this multivariate context (HR (95% CI) = 2.53 (1.35–4.73), p = 0.004) and a borderline significant impact for MRC1/CD206 (HR (95% CI) = 1.87 (1–3.51), p = 0.051).

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borderline significantp = 0.06so close (0.05 < p ≤ 0.1)

Examination of the model investigating the statistical interaction between STAT1 and TGFB2 showed that there was a borderline significant increase in HR for the TGFB2 high group of patients (HR (95% CI range) = 1.84 (0.97–3.46); p = 0.06) There was a significant increase in HR for the STAT1 high group of patients (HR (95% CI range) = 2 (1.08–3.71); p = 0.029), accounting for significant impact of age at diagnosis (HR (95% CI range) = 1.03 (1.01–1.05); p = 0.005).

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