Precision-cut liver slices as an ex vivo model to evaluate antifibrotic therapies for liver fibrosis and cirrhosis.

Hepatol Commun · 2024 · PMC11512631 · PMID 39445861

Europe PMC DOI

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0.0777

closest p · 1.6× alpha

0.0777

boldest claim

The sentences

marginal significancep = 0.0777so close (0.05 < p ≤ 0.1)

Erlotinib treatment of PCLS from CDAHFD-induced mouse cirrhotic livers for 72 hours significantly suppressed the expression of the profibrogenic genes Il6 , Col1a1 , and Timp1 (Figures 2 A, B) and suppressed Acta2 (also named αSMA ) expression with marginal significance ( p = 0.0777).

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