We did not find a significant difference in cortical demyelination between sections with high and low (Ig + ) B cells, although we did observe a slight trend towards higher cortical demyelination in sections with a high number of all B cells, IgG + B cells and IgM + B cells (Fig. 4 b).
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Intrathecal IgG and IgM synthesis correlates with neurodegeneration markers and corresponds to meningeal B cell presence in MS.
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