Analysis of RNA-seq data from bone marrow samples in the GSE34941 -GP11088 dataset revealed a notable trend: high GPX4 expression was associated with poor overall survival (OS) in BCR-ABL+ B-ALL patients (Fig. 5 I).
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Combined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells.
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