Functional genomic analysis of the 68-1 RhCMV-<i>Mycobacteria tuberculosis</i> vaccine reveals an IL-15 response signature that is conserved with vector attenuation.

Specifically, compared to baseline, lymphocytes (including T, B, and NK cells) showed a decreasing trend in abundance in the attenuated vaccine vector group while staying stable in the non-attenuated vaccine vector group, with increased neutrophils in the attenuated vaccine group.

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