Chromosomal aberrations of GS-intestinal and GS-diffuse tumors were similar with only a few marginally statistically significant ( p < 0.05; FDR < 0.27) differences between these two subgroups: losses of chromosomes 4p16.3, 6q14.1–q15, and 10p12.31–p12.1 occurred more often in GS-intestinal than GS-diffuse tumors, whereas gains of chromosome 8 occurred more often in GS-diffuse than GS-intestinal tumors.
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Chromosomal copy number based stratification of gastric cancer has added prognostic value to Lauren's histological classification.
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