As this might not capture functional variants that remain highly significant at some loci (that is, where the lead variant has an extremely strong association), we also considered variants having −log 10 ( P variant ) > 0.7 × (−log 10 ( P lead variant )), stipulating an r 2 of >0.2 for the lead variant and a P variant of <10 −5 in the GWAS.
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Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk.
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