Given the consistent trend in most of the datasets, we further investigated the abundance of m6A_WTAP + CD8 + T cells in different patients using immunofluorescence analysis of tissue microarrays; this revealed a decreasing trend of m6A_WTAP + CD8 + T cell infiltrates with a higher clinical stage (Fig. 7 c-f).
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RNA methylation patterns of tumor microenvironment cells regulate prognosis and immunotherapeutic responsiveness in patients with triple-negative breast cancer.
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