Fundamental mechanistic differences between ERAP1 allotypes suggest alterations in rate-limiting steps Our results suggest highly significant mechanistic differences between the ancestral allotype 1 of ERAP1 with the autoimmunity-protective allotype 10.
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Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties.
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