PALB2 , in particular, stands out due to its strong biological links and shared cancer risk profile with BRCA1/2 , and in fact, the enrichment of PGV-As across PALB2 , BRCA1 , and BRCA2 in the combined cohort was observed to be highly significant (OR 4.8, 95% CI, 2.8–7.8, FDR < 0.0001).
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Multiple Myeloma Risk and Outcomes Are Associated with Pathogenic Germline Variants in DNA Repair Genes.
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