How do cells communicate these needs and coordinate them with other biosynthetic pathways across and between cellular compartments? Chromatin assembly chaperones and innate immunity Given SMN’s primary cellular location in the cytoplasm, it was somewhat surprising to see so many highly significant GO terms ( Table 1 ) for nucleosome remodeling complexes like SWI/SNF, CHD, Brahma and nBAF.
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Proteomic analysis of the SMN complex reveals conserved and etiologic connections to the proteostasis network.
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