A highly significant decrease in the numbers of EdU-positive cells was observed in COX-2/TGF-β1 siRNA-transfected groups compared to the HKP and NC groups, whereas the COX-2 siRNA- and TGF-β1siRNA-treated group showed no significant difference (Fig. 2 C, P < 0.01).
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Administration of a combination of COX-2/TGF-β1 siRNAs induces hypertrophic scar fibroblast apoptosis through a TP53 mediated caspase pathway.
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