The ageing central nervous system in multiple sclerosis: the imaging perspective.

151 However, group-level treatment efficacy 6 shows a decreasing trend with increasing age, probably due to less MRI-visible inflammation. 152 Conversely, older patients tend to show incidental T 2 WM hyperintensities, mostly of vasculo-ischaemic origin. 153 Therefore, the question arises as to whether monitoring the appearance of new lesions in follow-up scans is the most appropriate way to assess treatment response in the ageing patient.

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