Aberrant salience in acute versus chronic schizophrenia: Do medication and positive symptoms make a difference?

menon.[ 12 ] Another study showed that a lifetime history of psychotic symptoms predicted aberrant salience, suggesting that it might be a trait.[ 14 ] Several studies have reported inconsistent findings regarding aberrant salience between healthy controls and psychotic patients, suggesting that it might be significant only in the severe end of the psychotic spectrum, indicating a state-dependent effect.[ 15 16 ] Hence, it is unclear if aberrant salience is present only in the early or acute stages of the illness or if it persists throughout, especially when symptoms are persistent.[ 17 ] Additionally, it is unclear whether asymptomatic patients on stable doses of antipsychotic medications for a long duration have significantly lower levels of aberrant salience due to the dampening effect of antipsychotics on dopamine.

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