Perturbations in eIF3 subunit stoichiometry alter expression of ribosomal proteins and key components of the MAPK signaling pathways.

In terms of GC content, while we observed little significant difference in GC content in the 5' UTR of eIF3d KD and eIF3e KD , there was a highly significant difference in the CDS and 3' UTR of these knock-downs in both downregulated and upregulated DTEGs, indicating that mRNAs with increased TE tend to have more GC-rich 3' UTRs and, surprisingly, CDS and vice versa.

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