Antigen-specific modulation of chronic experimental autoimmune encephalomyelitis in humanized mice by TCR-like antibody targeting autoreactive T-cell epitope.

As shown in Figs 5G and S3 for independent experiments, 2G10 TCRL Ab led to a highly significant reduction in the frequency of CD11b+/CD45 high -activated macrophages in the spinal cord and restored the composition of a healthy spinal cord with a predominant CD11b+/CD45 low population of tissue-resident microglial APCs.

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