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Increased DNMT1 acetylation leads to global DNA methylation suppression in follicular granulosa cells during reproductive aging in mammals.

BMC Genomics · 2024 · PMC11536882 · PMID 39497025

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a decreasing trendno p-value reported
Genome-wide methylation analysis of GCs revealed a decreasing trend in DNA methylation in old mice.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.