Compared with WT NLRX1, MT NLRX1 significantly increased the promoter activity of IL-6 but did not significantly affect the promoter activity of IFN-α and IFN-β, although an increasing trend was noticed.
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An NLR family member X1 mutation (p.Arg707Cys) suppresses hepatitis B virus infection in hepatocytes and favors the interaction of retinoic acid-inducible gene 1 with mitochondrial antiviral signaling protein.
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