A protein vaccine of RBD integrated with immune evasion mutation shows broad protection against SARS-CoV-2.

As the immunization process progressed, there was an overall trend toward increasing binding antibody levels.

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The body weight of mice in all groups showed a decreasing trend after infection, with the greatest decrease in the adjuvant group and the lowest decrease in the cRBD3 high-dose group (Fig. 6c ).

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