Non-local impact of distal airway constrictions on patterns of inhaled particle deposition.

Some relevant physical effects are not included in the current model, but could be incorporated in future: for example, airway wall elasticity [ 10 ], which could enable modelling of transient airway collapse; mechanical interdependence of the acini, which has been incorporated in previous ventilation models [ 58 ] and extrathoracic deposition, which may be significant for large particles [ 5 ].

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