Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia.

We found a highly significant risk association between AA homozygosity in the GRIA1 rs4958351 variant and the development of anti-L-Asp antibodies (OR = 3.43, 95%, CI = 1.04 to 11.25, p = 0.04).

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